The last scientist who worked in the Library was a mathematician, astronomer, physicist and the head of the Neoplatonic school of philosophy -- an extraordinary range of accomplishments for any individual in any age. Her name was Hypatia. She was born in Alexandria in 370. At a time when women had few options and were treated as property, Hypatia moved freely and unselfconsciously through traditional male domains. By all accounts she was a great beauty. She had many suitors but rejected all offers of marriage. The Alexandria of Hypatia's time -- by then long under Roman rule -- was a city under grave strain. Slavery had sapped classical civilization of its vitality. The growing Christian Church was consolidating its power and attempting to eradicate pagan influence and culture. Hypatia stood at the epicenter of these mighty social forces. Cyril, the Archbishop of Alexandria, despised her because of her close friendship with the Roman governor, and because she was a symbol of learning and science, which were largely identified by the early Church with paganism In great personal danger, she continued to teach and publish, until, in the year 415, on her way to work she was set upon by a fanatical mob of Cyril's parishioners. They dragged her from her chariot, tore off her clothes, and armed with abalone shells, flayed her flesh from her bones. Her remains were burned, her works obliterated, her name forgotten. Cyril was made a saint.
The glory of the Alexandrian Library is a dim memory. Its last remnants were destroyed soon after Hypatia's death. It was as if the entire civilization had undergone some self-inflicted brain surgery, and most of its memories, discoveries, ideas and passions were extinguished irrevocably. The loss was incalculable. In some cases, we know only the tantalizing titles of the works that were destroyed. In most cases, we know neither the titles nor the authors. We do know that of the 123 plays of Sophocles in the Library, only seven survived. One of those seven is Oedipus Rex. Similar numbers apply to the works of Aeschylus and Euripides. It is a little as if the only surviving works of a man named William Shakespeare were Coriolanus and A Winter's Tale, but we had heard that he had written certain other plays, unknown to us but apparently prized in his time, works entitled Hamlet, Macbeth, Julius Caesar, King Lear, Romeo and Juliet." (From Cosmos by Carl Sagan)